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College of
Engineering, Architecture and Technology

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CEAT building

Josh Ramsey, Ph.D., P.E.

Professor 

Dr. Josh Ramsey

Education

PhRMA Foundation Fellow
University of Kansas, 2007

 

Ph.D., Chemical  & Biomolecular Engineering
University of Illinois, 2006

 

M. S.,  Chemical Engineering
University of Illinois, 2003

 

B. S.,  Chemical Engineering
Oklahoma State University, 2000

Professional Experience 

Professional Honors and Affiliations 

Major Areas of Interest

Novel Gene Delivery Vectors

Macromolecular (Genes and Proteins) Drug Delivery

Directed Evolution of Enzymes

Virtual Design and Screening of Therapeutic Compounds

Recent Research Activities

Engineering Novel Gene Delivery Vectors

Safe and efficient delivery of genetic material remains a serious challenge limiting the field of gene therapy.  Our group is interested in developing novel methods for gene delivery.  We are currently funded by the National Science Foundation to investigate hybrid viral/synthetic gene delivery vectors that may ultimately lead to the design of better biomaterials for gene therapy vectors.

 

Macromolecular Drug Delivery

Protein therapeutics, like genes, pose a unique set of challenges when it comes to drug delivery.  We have been working with a polyethylene glycol-grafted-polylyine copolymer to encapsulate and deliver a range of proteins that can be used for treating cancer or providing protection from chemical warfare agents.

 

Virtual Design and Screening

Using neural networks and large chemical databases (NCI 60) of growth inhibition, we have developed a virtual design and screening platform to predict (i) the likely mechanism of action of a potentially novel chemotherapy drug and (ii) the growth inhibition effects of the potential drug.  This approach may lead to discovery of novel drugs for treating cancer or allow for in silico prediction of the synergistic effects of combination therapy.

 

Improving Industrial Relevant Enzymes and Microorganisms

Directed evolution is a technique that has been used to successfully re-engineer enzymes for a variety of applications.  Such enzymes show enhanced or novel substrate activity, improved stability in organic solvents, or greater thermostability.  Our lab is interested in using this technique to produce novel enzymes and microorganisms.

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