CEAT building

Yu Feng, Ph.D.

Dr. Yu Feng

Education

Ph.D., Mechanical Engineering
North Carolina State University, 2015

M.S., Mechanical Engineering
North Carolina State University, 2010

B.S., Engineering Mechanics
Zhejiang University, 2007

Industry Background

Research Assistant Professor, Mechanical Engineering

North Carolina State University, 2015

Research Scientist

DoD Biotechnology HPC Software Applications Institute (BHSAI), 2015

Postdoctoral Researcher, Mechanical Engineering

North Carolina State University, 2013

Major Areas of Research

Computational Fluid-Particle Dynamics and Advanced Numerical Methods
Physiologically Based Pharmacokinetic (PBPK) Modeling
Particulate Matter Transport Phenomena
Lung Aerosol Dynamics
Pulmonary Health Risk Assessment
Pulmonary Drug Delivery Optimization
Non-invasive Pulmonary Disease Diagnosis

Recent Research Activities

Toxic or Therapeutic Aerosol Transport and Uptake in the Respiratory Systems and Systemic Regions

The overall goal of our group is to understand and consider more underlying physics and chemistry, and provide non-invasive, cost-effective and accurate numerical tools. We make contributions to medical world and human life by providing well-posed solutions to patient-specific pulmonary health problems using multi-scale modeling techniques. By reconstructing a subject-specific whole lung model covering the entire lung conducting zone (from mouth to generation 17), we are able to use computational fluid-particle dynamics (CFPD) and Physiologically Based Pharmacokinetic (PBPK) models to simulate the transport, deposition, translocation, and clearance of inhaled toxic or therapeutic aerosols in the pulmonary routes and systemic regions Employing our numerical model and whole-lung geometry, we will able to provide high-resolution data and perform parametric sensitivity studies for lung geometric and operational factors that affect aerosol uptakes/clearance in the human bodies under realistic breathing patterns. Flow regimes, particle transport characteristics, and lung airway deformations will be visualized. The new insights generated by the CFPD-PBPK model will be significant for multiple biomedical applications, i.e., medical device improvements for effective and targeted drug deliveries, novel lung therapeutics, non-invasive disease diagnostic methodologies, and exposure health risks evaluations. Numerical simulations are performed on ANSYS Mechanical/CFD platforms, enhanced by in-house C programs.

Recent Publications (* denotes co-first authors)

Zhao, J., Feng, Y.*, Tian, G., Taylor, C., Arden, S. N. (2021). Influences of Puff Protocols and Upper Airway Anatomy on Cannabis Pharmacokinetics: A CFPD-PK Study. Computers in Biology and Medicine, 132, 104333
Hayati, H., Feng, Y.*, Hinsdale, M. (2021). Inter-species Variabilities of Droplet Transport, Size Change, and Deposition in Human and Rat Respiratory Systems: An In Silico Study, Journal of Aerosol Science, 154, 105761
Yi, H., Wang, Q., Feng, Y.*(2021). Computational analysis of chronic obstructive pulmonary disease (COPD) and expiration intensity effects on the cough-driven mucus movement and clearance in an idealized upper airway model using Volume of Fluid (VOF) method. Physics of Fluids, 33, 021903
Feng, Y.*, Zhao, J., Spinolo, M., Lane, K., Laung, D., Marshall, D., Mlinaric, P. (2021). Assessing the Filtration Effectiveness of an Air Sanitizer on Airborne SARS-CoV-2 Laden Droplets in a Patient Room: A CFPD Study. Aerosol and Air Quality Research, 21(5), 20608
Feng, Y.⁺, Zhao, J. *, Hayati, H. *, Sperry, T. *, Yi, H. * (2021). Tutorial: Understanding the transport, deposition, and translocation of particles in human respiratory systems using Computational Fluid-Particle Dynamics and Physiologically Based Toxicokinetic models. Journal of Aerosol Science, 151, 105672
Kolewe, E., Feng, Y., Fromen, C. (2020). Realizing Lobe-Specific Aerosol Targeting in a 3D Printed In Vitro Lung Model. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 33(0)
Chen, X., Zhou, X., Xia, X., Xie, X., Lu, P., Feng, Y. (2020). Modeling of the transport, hygroscopic growth, and deposition of multi-component droplets in a simplified airway with realistic thermal boundary conditions. Journal of Aerosol Science, 151, 105626
Feng, Y.⁺, Marchal, T., Sperry, T. *, Yi, H. * (2020). Influence of Wind and Relative Humidity on the Social Distancing Effectiveness to Prevent COVID-19 Airborne Transmission: A Numerical Study. Journal of Aerosol Science, 147, 105585
Yi, H. *, Feng, Y.⁺, Park, H., Wang, Q. (2020). Configuration predictions of large liquefied petroleum gas (LPG) pool fires using CFD method. Journal of Loss Prevention in the Process Industries, 116, 104099
Zhao, J.*, Feng, Y.⁺, Fromen, C. (2020). Glottis Motion Effects on the Inhaled Particle Transport and Deposition in a Subject-Specific Mouth-to-Trachea Model: An in silico Study. Computers in Biology and Medicine. 116, ID: 103532.
Zhao, J.*, Feng, Y., Bezerra, M., Wang, J., Sperry, T. (2019). Numerical Simulation of Welding Fume Lung Dosimetry. Journal of Aerosol Science. 135, 113-129
Yi, H.*, Feng, Y.⁺, Wang, Q. (2019). Computational Fluid Dynamics (CFD) Study of Heat Radiation from Large Liquefied Petroleum Gas (LPG) Pool Fires. Journal of Loss Prevention in the Process Industries. 61, 262-274
Haghnegahdar, A.*, Zhao, J.*, Feng, Y.⁺ (2019). Lung aerosol dynamics of airborne influenza A virus-laden droplets and the resultant immune system responses: An in silico study. Journal of Aerosol Science, 134, 34-55
Haghnegahdar, A.*, Zhao, J.*, Kozak, M.*, Williamson, P., Feng, Y. ⁺(2019). Development of a Hybrid CFD-PBPK Model to Predict the Transport of Xenon Gas Around a Human Respiratory System to Systemic Regions. Heliyon, 5(4), e01461
Amer, M., Ramsey, J., Feng, Y. (2019). Using CFD Simulations and Statistical Analysis to Correlate Oxygen Mass Transfer Conditions in a Stirred0Tank Bioreactor. Biotechnology Progress, 35(3), e2785
Feng. Y.⁺, Zhao, J.*, Kleinstreuer, C., Wang, Q., Wang, J., Wu, D.H., Lin, J. (2018). An in silico Inter-subject Variability Study of Extra-thoracic Morphology Effects on Inhaled Particle Transport and Deposition. Journal of Aerosol Science, 123, 185-207.